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KMID : 0371320080750050307
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Journal of the Korean Surgical Society
2008 Volume.75 No. 5 p.307 ~ p.314
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The Prognostic Value of CA19-9 in Patients with Colorectal Cancer
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Kim Min-Soo
Joo Ho-Min
Hong Seong-Woo
Kang Yun-Kyung
Chun Jung-Woo
Chang Yeo-Goo
Paik In-Wook
Lee Hyuck-Sang
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Abstract
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Purpose: There has been much debate about the significance of the CA19-9 level for predicting the prognosis of colorectal cancer patients. This study aimed to evaluate the prognostic value of the preoperative serum CA19-9 level and the CA19-9 expression in the tumor tissues of colorectal cancer patients
Methods: One hundred patients with colorectal cancer and who had been treated by resection were studied. We assessed the correlations of the preoperative serum CA19-9 level and the status of the CA19-9 immunohistochemical staining with the clinicopathologic features, including the prognosis of the patients.
Results: The preoperative serum CA19-9 level had significant correlation with the status of CA19-9 immunohistochemical staining. The presence of distant metastasis was significantly correlated with an elevated level of serum CA19-9. The depth of tumor, the presence of lymph node metastasis, the TNM stage and tumor cell differentiation were significantly correlated with the status of the CA19-9 immunohistochemical staining. In addition, the gross morphology, depth of tumor, the presence of lymph node metastasis, the TNM stage, the status of the CA19-9 immunohistochemical staining and the serum CEA level were correlated with survival on univariate analysis. However, multivariate analysis did not validate the status of CA19-9 immunohistochemical staining as a significantly independent predictor of the prognosis.
Conclusion: The CA19-9 expression was frequently observed in advanced stage tumor tissue, yet its expression in tumor tissue or the preoperative CA19-9 serum level did not show independent prognostic value for colorectal cancer patients. (J Korean Surg Soc 2008;75:307-314)
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KEYWORD
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Colorectal cancer, CA19-9 expression, Immunohistochemical stain, Clinicopathologic feature, Prognostic indicator
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